Publications


StrIDR: a database of intrinsically disordered regions of proteins with experimentally resolved structures
K. Majila, S. Viswanath
bioRxiv, 2024


An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome
X. Liu, Y. Zhang, Z. Wen, Y. Hao, C. A.S. Banks, J. Cesare, S. Bhattacharya, S. Arvindekar, J. J. Lange, Yixuan Xie, B. A. Garcia, B. D. Slaughter, J. R. Unruh, S. Viswanath, L. Florens, J. L. Workman, and M. P. Washburn
PNAS, 2024


Frontiers in integrative structural biology: modeling disordered proteins and utilizing in situ data
K. Majila*, S. Arvindekar*, M. Jindal, S. Viswanath
arXiv, 2024
Key Figure
DOI PDF


The molecular architecture of the desmosomal outer dense plaque by integrative structural modeling
S. Pasani, K. Menon, S. Viswanath
bioRxiv, 2024


Optimizing representations for integrative structural modeling using Bayesian model selection
S. Arvindekar, A. S. Pathak, K. Majila, S. Viswanath
Bioinformatics, 2024


Recent methods from statistical inference and machine learning to improve integrative modeling of macromolecular assemblies
S. Arvindekar*, K. Majila*, S. Viswanath
Springer Methods in Mol Bio, in press, 2024
Key Figure
DOI PDF


Identification of potential modulators of IFITM3 by in-silico modeling and virtual screening
V. Tiwari and S. Viswanath
Scientific Reports, 2022


Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination
S. Arvindekar, M. J. Jackman, J.K.K. Low, M.J. Landsberg, J.P. Mackay, S. Viswanath
Protein Science, 2022


PrISM: precision for integrative structural models
V. Ullanat, N. Kasukurthi, S. Viswanath
Bioinformatics, 2022


A Framework for Stochastic Optimization of Parameters for Integrative Modeling of Macromolecular Assemblies
S. Pasani, S. Viswanath
Life (Spl. Issue on Computational Modeling of Kinetics in Biological Systems), 2021


CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation
A. Brilot, A.S. Lyon, A. Zelter, S. Viswanath, A. Maxwell, R. Johnson, K.C. Yabut, M. MacCoss, E. Muller, A. Sali, T.N. Davis, D. A. Agard
eLife, 2021


Using Integrative Modeling Platform to compute, validate, and archive a model of a protein complex structure
D. Saltzberg, S. Viswanath, I. Echeverria, I.E. Chemmama, B. Webb, A. Sali
Protein Science, 2021
PDF Website


Modeling biological complexes using Integrative Modeling Platform, Biomolecular Simulations Series
D. Saltzberg, C.H. Greenberg, S. Viswanath, I.E. Chemmama, B. Webb, R. Pellarin, I. Echeverria, A. Sali
Methods in Molecular Biology, 2019


Optimizing model representation for integrative structure determination of macromolecular assemblies
S. Viswanath and A. Sali
PNAS, 2019


Integrative structure modeling with the Integrative Modeling Platform
B. Webb, S. Viswanath, M. Bonomi, R. Pellarin, C.H. Greenberg, D. Saltzberg, A. Sali
Protein Science, 2018


Assessing Exhaustiveness of Stochastic Sampling for Integrative Modeling of Macromolecular Structures
S. Viswanath, I.E. Chemmama, P. Cimermancic, A. Sali
Biophysical Journal, 2017


The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling.
S. Viswanath, M. Bonomi, S.J. Kim, V.A. Klenchin, K.C. Taylor, K.C. Yabut, N.T. Umbreit, H.A. Van Epps, J. Meehl, M.H. Jones, D. Russel, J.A. Velazquez-Muriel, M. Winey, I. Rayment, T.N. Davis, A. Sali, E.G. Muller
Molecular Biology of the Cell, 2017


Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experiment
M.F. Lensink, S. Velankar, …, S. Viswanath, R. Elber, …, (several authors), S.J. Wodak
Proteins, 2016
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Extension of a protein docking algorithm to membranes and applications to amyloid precursor protein dimerization
S. Viswanath, L. Dominguez, L.S. Foster, J.E. Straub, R. Elber
Proteins, 2015
PDF Website


Architecture of the human and yeast general transcription and DNA repair factor TFIIH
J. Luo, P. Cimermancic, S. Viswanath, C. C. Ebmeier, B. Kim, M. Dehecq, V. Raman, C.H. Greenberg, R. Pellarin, A. Sali, D. Taatjes, S. Hahn, J. Ranish
Molecular Cell, 2015
PDF Website Dataset Github News


DOCK/PIERR: web server for structure prediction of protein-protein complexes
S. Viswanath, D.V.S. Ravikant, R. Elber
Protein Structure Prediction, Methods in Molecular Biology, 2014
PDF Website


Improving ranking of models for protein complexes with side chain modeling and atomic potentials
S. Viswanath, D.V.S. Ravikant, R. Elber
Proteins, 2013
PDF Website Github


Analyzing milestoning networks for molecular kinetics: Definitions, algorithms, and examples
S. Viswanath, S.M. Kreuzer, A.E. Cardenas, R. Elber
The Journal of Chemical Physics, 2013
PDF Website