Welcome to the Integrative Structural Biology Lab!

ISB lab logo

We are an interdisciplinary computational structural biology group in NCBS-TIFR, Bangalore.

Broadly, we seek to understand how proteins are organized in cells. We do this by characterizing structures of proteins at multiple scales, ranging from binary complexes to macromolecular assemblies and nanoscale architectures. These structures are key to understanding the mechanistic details of cellular processes in normal and disease states. They provide answers to questions such as: how do these molecular machines function? How did they evolve? How are they assembled and regulated in the cell? What do they tell us about basic architectural design principles in biology?

One focus of our group is to develop rigorous methods and software for computational modeling of protein organization. We’re inspired by algorithms from computational statistics, statistical physics, machine learning and optimization, computer vision, and graph theory. We aim to produce algorithms and software that we and others can use.

Another focus lies in characterizing the structures and functions of specific assemblies in close collaborations with (experimental) cell and structural biologists.

Upcoming events

Symposium on Big Data Algorithms for Biology

IISc Bangalore, May-June 2024

Cryo electron microscopy and 3D image processing (CEM3DIP)

Bangalore, June-July 2024

Join us!

Interested in collaborating with us or joining us? Please get in touch. Also check out the Opportunities page.


We are at Lab 15, ELC 1st floor in NCBS.

Address: National Center for Biological Sciences (NCBS),
Tata Institute for Fundamental Research (TIFR),
GKVK, Bellary Road, Bangalore, India 560065

Phone: +91-080-6717-6152

Email: shruthiv AT THE RATE OF ncbs DOT res DOT in

Twitter: @shruthiLab